CapZ and Tropomodulin regulate sarcomere length by capping which ends of actin filaments?

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Study for the Anatomy and Physiology Muscular System Test. Prepare with flashcards and multiple choice questions; each question provides hints and explanations. Get ready to excel in your exam!

Multiple Choice

CapZ and Tropomodulin regulate sarcomere length by capping which ends of actin filaments?

Explanation:
Actin filament ends are regulated to keep sarcomere length stable. Thin filaments extend from the Z-disc toward the M-line, with the barbed (plus) end at the Z-disc and the pointed (minus) end toward the M-line. CapZ binds the barbed end at the Z-disc, halting dynamics there, while Tropomodulin caps the pointed end at the minus end near the M-line, preventing changes at that end as well. This pairing maintains a constant filament length during contraction, which is why the best description is that CapZ caps the barbed end at the Z-disc and Tropomodulin caps the pointed end.

Actin filament ends are regulated to keep sarcomere length stable. Thin filaments extend from the Z-disc toward the M-line, with the barbed (plus) end at the Z-disc and the pointed (minus) end toward the M-line. CapZ binds the barbed end at the Z-disc, halting dynamics there, while Tropomodulin caps the pointed end at the minus end near the M-line, preventing changes at that end as well. This pairing maintains a constant filament length during contraction, which is why the best description is that CapZ caps the barbed end at the Z-disc and Tropomodulin caps the pointed end.

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